Fugenbio’s Fungus May Help Learning and Memory

Ceriporia lacerata has the neuroprotective effects

Fugenbio, a Seoul-based pharmaceutical company developing the functional and medical foods using the original materials for metabolic diseases and aging, announced on December 8th that its novel fungus ‘Ceriporia lacerata (C. lacerata)’ had showed to be beneficial to cognitive function.

In collaboration with Dr. Jong-Sang Kim of Kyungpook National University, Fugenbio published the article titled ‘Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model’ in the journal ‘Food Science and Biotechnology’ on July 16th.

In the experiments, C. lacerate (a species of white rot fungi) showed the anti-oxidant and anti-glutamate effects and restored the spatial learning and memory impairment in scopolamine-treated mice.

According to the company, these findings suggest that C. lacerata may have therapeutic potentials for AD particularly considering that C. lacerata also has the anti-diabetic effects, Supporting Fugenbio’s expectation, emerging evidences indicate that insulin has a role in proteostasis and insulin resistance exerts negative influence on the clearance of beta-amyloid and the phosphorylation of tau. Moreover, diabetes is a risk factor for Alzheimer’s disease (AD) and impairs the insulin signaling in AD brains.

Meanwhile, Fugenbio succeeded in the artificial culture of C. lacerata and the materialization of its innovative ‘CLEPS’, the key pharmaceutical ingredients of C. lacerata mycelium.

<Journal Reference>

Lee S, Lim JS, Yun HS, Kim Y, Jeong S, Hwang SD, Kim JW, Oh J, Kim JS. 
Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model. Food Sci Biotechnol. 2021 Jul 16;30(8):1107-1116. 
doi: 10.1007/s10068-021-00945-5.